Circulating calprotectin - the power to assess inflammation
- februar 2024
We are witnessing a growing demand and interest in circulating calprotectin, which we see as a testament to the biomarker’s clinical value and potential to improve patient care. In response to this heightened interest, we have expanded our global footprint by establishing partnerships with new international collaborators. We are also delighted to welcome new routine users of Gentian GCAL® Calprotectin Immunoassay, our turbidimetric plasma and serum calprotectin immunoassay, on a global scale.
Circulating calprotectin - assessment of inflammation
Calprotectin in plasma and serum serves as a sensitive and early biomarker for detecting inflammation and inflammatory responses in infections. Elevated levels of calprotectin are released into the bloodstream during inflammation, and the concentration of calprotectin corresponds to the extent of inflammation. Its application has been documented in various conditions, encompassing both infectious and non-infectious inflammatory scenarios.
The GCAL® is the first turbidimetric assay for the quantitative measurement of calprotectin in plasma and serum intended as an aid in the detection and assessment of inflammation.
GCAL® calprotectin in the ED and ICU – recent studies
Numerous studies have demonstrated the substantial value of plasma and serum calprotectin in the detection and evaluation of infections within the emergency department (ED) and intensive care unit (ICU).
The year 2023 was marked by publications of three notable clinical studies about calprotectin in the emergency setting, using the GCAL® assay:
Karolinska University Hospital, Stockholm : This study demonstrates the feasibility of using calprotectin to aid in acute assessment and transfer decisions from the ED to the ICU or ward.
Charité University, Berlin : Preclinical results from this study, presented at ECCMID 2023, indicate the potential of calprotectin in severity assessment to predict infection, sepsis and mortality.
Health Economic Study: Exploring the predictive use of plasma calprotectin, which facilitates clinical decision making in cases of suspected sepsis, indicates that such determination has a dual impact - cost-saving and life-saving - on the healthcare system.
Calprotectin in immunology and rheumatology
Building on a vast amount of scientific evidence, calprotectin is increasingly recognised and extended to daily clinical use in immunology and rheumatology departments. An official recommendation to measure S100 proteins has been incorporated into the EULAR guideline for IL-1 mediated autoinflammatory diseases, indicating a significant step towards the routine use of calprotectin measurement in the expanding field of immunology. This development anticipates a steadily increase in adoption and routine use of calprotectin measurements within clinical routine protocols.
Literature overview: Clinical value of plasma and serum calprotectin
Several noteworthy scientific publications and reviews have discussed circulating calprotectin. You will find an overview of selected literature on calprotectin on our webpage in certain focus areas:
- Rheumatoid Arthritis (RA)
- Juvenile Idiopathic Arthritis (JIA)
- Still’s disease (sJIA and AOSD)
- Bacterial infections and sepsis
- COVID-19
Highlight reviews from 2023:
S100A8/A9: An emerging player in sepsis and sepsis-induced organ injury
Circulating Calprotectin (cCLP) in autoimmune diseases.