Diskusjon Triggere Porteføljer Aksjonærlister

NANO Fundamentale Forhold (NANOV)

Denne til Genmab som ser ut til å hete Epcoritamab har det vel ikke vært nevnt noe særlig om tidligere. Men at det var bispcifics på gang er ikke noen nyhet ihvertfall…

Ser ut som Genmab kjører et bredt studie innen mange b-celle-indikasjoner med
completion date 2022 og så må de evnt videre på en pivotal studie – så er nok noen år fram i tid…

Foreløpige resultater viser ORR 36.8 % og CR 5,3 % i en populasjon på 22 pas (mest testet dose), men dette er for alle indikasjoner og den er ikke ferdig rekruttert.
For FL så fikk 5 av 5 respons, men ingen CR.
En del Aes som medfører ekstra medisinering for å undertrykke bivirkninger.
Alt I alt er det veldig mye interessant pdf`en under – spesielt om cd3xcd20, men også noe om duahexabody…
Men altså - det er sikkert mulig å få til et samarbeid med Genmab også ift til å kombinere bispcifics cd3xcd20 med en mild cd37 behandling – Bygger igrunnen bare videre på min oppfatning om at milde, forbigående bivirkninger pga Engangsbehandling kombinert med et annet angrepsmål er gullegget til Nano, så kan fort være en oppside også med den tanken i bakhodet.
Og for pasientene er det jo veldig positivt at det er så mange medisinkandidater i utprøving!

https://ir.genmab.com/static-files/60467b61-f6ed-4196-ae15-455d57d9f919

Her er info fra preklinisk juni 2019:
“DuoBody-CD3xCD20 induced potent anti-tumor activity in vitro and in vivo , also in the presence of competing CD20 antibodies. DuoBody-CD3xCD20 was ∼100-fold more potent in vitro than another CD3xCD20 bsAb that is in clinical development. SC administration in cynomolgus monkeys induced profound B-cell depletion, which was associated with reduced plasma cytokine levels compared to IV administration. A First-in-Human trial to evaluate the safety and preliminary efficacy of DuoBody-CD3xCD20 by SC administration in patients with B-cell malignancies is currently enrolling (NCT03625037).”

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Oslo, Norway, 4 May 2020

Nordic Nanovector Announces Changes to its Executive Management Team

Oslo, Norway, 4 May 2020

Nordic Nanovector ASA (OSE: NANO) today announces changes to its Executive Management Team.

As a result of the cost-saving initiatives announced on 2 April 2020, the Board of Directors of Nordic Nanovector has restructured the senior management team. The restructuring has resulted in the number of executives being reduced from nine to seven.

Malene Brondberg, Vice President Investor Relations and Corporation Communications, has been appointed CFO, effective 1 May, reporting to Lars Nieba, interim CEO. Malene Brondberg will in her new role as CFO be responsible for the areas Finance, Human Resources and Investor Relations.

Tone Kvåle and Rita Dege leave from their respective roles as Chief Financial Officer and Chief Human Resources Officer as of 1 May 2020.

Ms. Brondberg joined Nordic Nanovector in February 2018 bringing over 20 years’ operational experience in the financial services sector. Her career has included Global Head of Research managing a team of 67 people and member of the Executive Committee of the Nordic investment bank ABG Sundal Collier. Since 2011, Ms. Brondberg has worked as a management consultant within the financial sector, acting as an advisor in relation to investor relations and funding, and has held various interim CEO, COO and Head of Compliance/HR/Finance management positions.

For further information, please contact:

IR enquiries

Jan H. Egberts, Chairman of Nordic Nanovector

Tel: +31 614672518

Email: [email protected]

Media Enquiries

Mark Swallow/Frazer Hall/David Dible (Citigate Dewe Rogerson)

Tel: +44 203 926 8535

Email: [email protected]

About Nordic Nanovector:

Nordic Nanovector is committed to develop and deliver innovative therapies to patients to address major unmet medical needs and advance cancer care. The Company aspires to become a leader in the development of targeted therapies for haematological cancers.Nordic Nanovector’s lead clinical-stage candidate is Betalutin®, a novel CD37-targeting antibody-radionuclide-conjugate designed to advance the treatment of non-Hodgkin’s lymphoma (NHL). NHL is an indication with substantial unmet medical need, representing a growing market forecast to be worth nearly USD 29 billion by 2026. Nordic Nanovector retains global marketing rights to Betalutin® and intends to actively participate in the commercialisation of Betalutin® in the US and other major markets.
Further information can be found at www.nordicnanovector.com.

Forward-looking statements

This press release contains certain forward-looking statements. These statements are based on management’s current expectations and are subject to uncertainty and changes in circumstances, since they relate to events and depend on circumstances that will occur in the future and which, by their nature, will have an impact on Nordic Nanovector’s business, financial condition and results of operations. The terms “anticipates”, “assumes”, “believes”, “can”, “could”, “estimates”, “expects”, “forecasts”, “intends”, “may”, “might”, “plans”, “should”, “projects”, “targets”, “will”, “would” or, in each case, their negative, or other variations or comparable terminology are used to identify forward-looking statements. These forward-looking statements are not historic facts. There are a number of factors that could cause actual results and developments to differ materially from those expressed or implied in the forward-looking statements. Factors that could cause these differences include, but are not limited to, risks associated with implementation of Nordic Nanovector’s strategy, risks and uncertainties associated with the development and/or approval of Nordic Nanovector’s product candidates, ongoing and future clinical trials and expected trial results, the ability to commercialise Betalutin®, technology changes and new products in Nordic Nanovector’s potential market and industry, Nordic Nanovector’s freedom to operate (competitors patents) in respect of the products it develops, the ability to develop new products and enhance existing products, the impact of competition, changes in general economy and industry conditions, and legislative, regulatory and political factors. No assurance can be given that such expectations will prove to have been correct. Nordic Nanovector disclaims any obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

This information is subject to a duty of disclosure pursuant to Sections 4-2 and 5-12 of the Securities Trading Act.

This release was sent by Nordic Nanovector AS

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These findings could be also used to improve patient selection, which is essential for increasing RIT efficacy and safety.

https://www.nature.com/articles/s41375-019-0677-4

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“The analysis of the biodistribution at various time points and SPECT-CT imaging at 48 h after injection of 177Lu-lilotomab and 177Lu-rituximab in Ramos and DOHH2 cell xenografts (Supplementary Fig. 1b, c) showed that radioactivity uptake was higher in Ramos than in DOHH2 cell tumors for both 177Lu-mAbs. This was mainly due to the larger size (100–200 mm3 versus 50–75 mm3) of the Ramos tumors (Supplementary Fig. 1b, c) at the time of injection. Conversely, the uptake of the two 177Lu-mAbs was similar in each model, although the number of CD20 receptors was higher than that of CD37 receptors in both DOHH2 and Ramos cells (Supplementary Fig. 1d). This could be explained by higher CD37 receptor internalization compared with CD20.”

177Lu-rituximab?? :open_mouth:
Noe de har laget til bare for å kunne bruke under denne testinga…? :thinking:

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Gammelt nytt???

Over to uker siden den posten, så gammelt nytt nå, ja…
Edith: Artikkelen i Nature er også noen måneder gammel.

Ja, er fra des 2019, men kan ikke huske å ha sett den inne på TI?

Nei, tror ikke jeg har sett den tidligere her. Så sånn sett kan det være nytt. Husker det ikke. En stund siden det har vært noen MZL-diskusjon.

Hm, vil vel anta at Covid-19 har bydd på snublesteiner for flere farmasiselskaper enn Nano.

Anyway, her er link til transkriptet for Nanos Q1 2020, fra Yahoo Finance.
Enjoy, med eller uten munnbind:)!

https://finance.yahoo.com/news/edited-transcript-nano-ol-earnings-155454561.html

Tror ikke du får et svar med to streker under på det spørsmålet. Konsensus her er at Nano får godkjent Betalutin uansett grunnet differensiert produktprofil

Fast track mister de ikke uansett. Antar du mener om de går glipp av muligheten til AA for paradigme og det tviler jeg sterkt på… Løpet mot godkjenning legges i samråd med FDA og selv om copanlisib skulle få en regular approval innen nano søker AA, så vil jeg tro at fda ser nødvendigheten av en differensiert behandling og at for enkelte pasientgrupper innen 3FL er ikke copanlisib et alternativ og derfor vil de nok ha B også på markedet asap… Bivirkningsprofilen spiller en veldig stor rolle her, men også effekt, dor (og dor for cr) samt særegenheten i behandlingsmetode/angrepsmål er med i den vurderingen…

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Spennende eller ikke?

Nano har søkt om å få bli godkjent for opptak i ett forskningsprogram kalt KAPPA i Tsjekkoslovakia. Prosjektet er så langt akseptert til å gå videre til evalueringsfasen som går frem til September. Deretter eventuelt prosjektoppstart fra Oktober av.

Det spennende er at prosjektet heter Efficient Low-energy Electron Cancer Therapy with Terbium-161

Terbium-161 husker jeg ble nevnt i denne artikkelen i 2018. Tar Nano ballen videre nå?:

Prosjektet ser ut til å være ett samarbeid med flere men det er Nano som står som søker for støtten noe som kan tyde på at de har en ledende rolle i prosjektet (?).

En interessant research paper hvor det er mye vurdering av 161tb vs lu177.
edit: link lagt til :grin:
https://www.thno.org/v06p1611.htm

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Synes det virker jævlig spennende!

Bra funn!:+1:

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Hvor fant du dette?

Snakker vi mnok her??

Vet ikke om det går an å trekke så mye ut av det, men er vel CZK når jg leser gjennom dokumentet…

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Interessant lesing for de som er interessert i NANO og RPT (Radiopharmaceutical therapy).

https://www.nature.com/articles/s41573-020-0073-9

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Flott! Men som alltid: 300 kildehenvisninger, ikke et kvidder om Betalutin.

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Nice funn @larosaleda!

Kan RIT stå foran et gjennombrudd i nærmeste fremtid?

With the recent FDA approval of several RPT agents, the remarkable potential of this treatment is now being recognized.

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Einarsson bekerefter i dagens podcast at interessen fra store BP i særdeleshet er tilstede om dagen! For deres selskaper

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