De har nuca kraftig her:
Maximum tumor uptake in vivo was 45% IA/g in MEC-2 tumors and 15% IA/g in DOHH-2 tumors.
Survival was significantly extended in DOHH-2 xenograft-bearing mice treated with NNV003 (2-30 mg/kg) and 177Lu-NNV003 (200-400 MBq/kg) compared to control groups (p<0.0001).
In the MEC-2 model, 200 MBq/kg 177Lu-NNV003 extended survival compared to the NNV003 and the 177Lu-isotype treatment (p<0.025).
In mice bearing REC-1 xenografts, both 50 and 100 MBq/kg 177Lu-NNV003 improved survival compared to control groups (p<0.02).
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Hvor er blodkreften? Hvordan arter blodkreft seg? Tumorklumper i blodet?
Sterk statistisk signifikant virkning på tumor.
Overlevelsen oppgis til signifikant, men ikke hvor mange dager. For sterk/ikke optimalisert dose kanskje.