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BergenBio (BGBIO)

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#752

Ser ut som BergenBio hat fått late breaker abstract på SITC. Syns de kunne kostet på seg en børsmelding for dette.

https://sitc.sitcancer.org/2018/abstracts/titles/late-breaking/


#753

Dette er den samme pasientpopulasjonen som ble rapportert på ved World Lung 2018 så her må de vel ha ytterligere informasjon å komme med?


#754

Ut i fra tittelen burde det være gode muligheter for mer fullstendig data på SITC:

“A Phase II study of bemcentinib (BGB324), a first-in-class selective AXL inhibitor, in combination with pembrolizumab in patients with advanced NSCLC: Analysis of the first stage”


#755

Se det opp mot den andre poseteren de også skal ha der: “Predictive and pharmacodynamic biomarkers associated with treatment with the oral selective AXL Inhibitor bemcentinib in combination with pembrolizumab in patients with advanced NSCLC and Melanoma”

De er jo litt like? Blir spennende å se om det er noe forskjell der. Tenker jo at late-breaking på SITC-krever litt futt!

De pressemeldte ikke det og de pressemeldte ikke meldingen i dag. De pleier vanligvis å være flinke på slike ting så dette likner ikke dem.


#756

BerGenBio to present late-breaking abstract on Phase II trial of bemcentinib in combination with KEYTRUDA® in advanced NSCLC at SIT

· Combination of selective AXL inhibitor bemcentinib and KEYTRUDA® featured in
late breaking abstract at leading IO conference SITC
· Analysis comprises stage 1 (n=24) in PhII trial in 2L advanced NSCLC
· Stage 2 open and enrolling
Bergen, Norway, 2 November 2018 - BerGenBio ASA (OSE:BGBIO) announces that the
analysis of the first stage of its Phase II clinical trial with bemcentinib, a
first-in-class selective oral AXL inhibitor, in combination with the anti-PD-1
therapy KEYTRUDA® (pembrolizumab) in patients with previously treated, advanced
non-small cell lung cancer (NSCLC) has been selected as a Late-breaking Abstract
at the annual Society for Immunotherapy in Cancer (SITC) 2018 congress in
Washington D.C. (7-10 November 2018).

Late-breaking abstracts highlight novel and potentially practice-changing
studies, and their acceptance for presentation is subject to favourable
assessment by a panel of clinical and scientific experts. In total, only 21
abstracts were accepted in the late-breaking category at this year’s SITC
congress: https://sitc.sitcancer.org/2018/abstracts/titles/late-breaking/

An update from BerGenBio’s biomarker and companion diagnostic programme will
also be presented as a poster within the regular abstract section. See details
below.

Presentations at SITC: Friday 9 November, 12:45 - 2:15 p.m. and 6:30 - 8

p.m. EST, Hall E
A Phase II study of bemcentinib (BGB324), a first-in-class selective AXL
inhibitor, in combination with pembrolizumab in patients with advanced
NSCLC: Analysis of the first stage
· Matthew Krebs, PhD et al
· Category: 33rd Annual Meeting Late-Breaking Abstracts
· Presentation number: P715
Predictive and pharmacodynamic biomarkers associated with treatment with
the oral selective AXL Inhibitor bemcentinib in combination with
pembrolizumab in patients with advanced NSCLC and Melanoma
· Robert Holt, PhD, et al
· Category: Biomarkers and Immune Monitoring
· Presentation number: P115

The full abstracts will be published on November 6th at 8 a.m. Eastern time at
https://www.sitcancer.org/2018/home.

  • END -

About SITC

The Society for Immunotherapy of Cancer (SITC) is the world’s leading member
-driven organisation specifically dedicated to improving cancer patient outcomes
by advancing the science and application of cancer immunotherapy. Over 4,000
delegates are expected to attend the SITC 33rd Annual Congress in Washington
D.C. on Nov 7-10 2018. For more information please see www.sitcancer.org

About the BGBC008 trial: A Phase II study of bemcentinib in combination with
pembrolizumab in patients with previously treated advanced NSCLC

The BGBC008 trial is a phase II multi-centre open-label study of bemcentinib in
combination with KEYTRUDA (pembrolizumab) in previously treated, immunotherapy
naïve, patients with advanced adenocarcinoma of the lung, the most common form
of non-small cell lung cancer (NSCLC). The objective of the trial is to
determine the anti-tumour activity of this novel drug combination. Responses
will be correlated with biomarker status (including AXL kinase and PD-L1
expression).

For more information please access trial NCT03184571 at www.clinicaltrials.gov.

About AXL

AXL kinase is a cell membrane receptor and an essential mediator of
the biological mechanisms that drive aggressive and life-threatening diseases.
In cancer, AXL drives tumour survival, treatment resistance and spread, as well
as suppressing the body’s immune response to tumours. AXL expression has been
established as a negative prognostic factor in many cancers. AXL inhibitors,
therefore, have potential value at the centre of cancer combination therapy,
addressing significant unmet medical needs and multiple high-value market
opportunities.

About BerGenBio ASA

BerGenBio is a clinical-stage biopharmaceutical company focused on
developing transformative drugs targeting AXL as a potential cornerstone of
therapy for advanced and aggressive cancers. The company’s proprietary lead
candidate, bemcentinib, is a potentially first-in-class selective AXL inhibitor
in a broad phase II clinical development programme. Ongoing clinical trials are
investigating bemcentinib in multiple solid and haematological tumours, in
combination with current and emerging therapies (including immunotherapies,
targeted therapies and chemotherapy), and as a single agent.

In parallel, BerGenBio is developing a companion diagnostics test to
identify patient populations most likely to benefit from bemcentinib: this is
expected to facilitate more efficient registration trials and support a
precision medicine-based commercialisation strategy.

BerGenBio is based in Bergen, Norway with a subsidiary in Oxford, UK.
The company is listed on the Oslo Stock Exchange (ticker:
BGBIO). www.bergenbio.com

Contacts

Richard Godfrey
CEO, BerGenBio ASA
+47 917 86 304

Rune Skeie, CFO, BerGenBio ASA
[email protected]
+47 917 86 513

International Media Relations

David Dible, Mark Swallow, Marine Perrier, Citigate Dewe Rogerson
[email protected]
+44 207 638 9571

Media Relations in Norway

Jan Petter Stiff, Crux Advisers
[email protected]
+47 995 13 891

Forward looking statements

This announcement may contain forward-looking statements, which as such are not
historical facts, but are based upon various assumptions, many of which are
based, in turn, upon further assumptions. These assumptions are inherently
subject to significant known and unknown risks, uncertainties and other
important factors. Such risks, uncertainties, contingencies and other important
factors could cause actual events to differ materially from the expectations
expressed or implied in this announcement by such forward-looking statements.

This information is subject to the disclosure requirements pursuant to section 5
-12 of the

Ekstern link: https://newsweb.oslobors.no/message/462666

Nyheten er levert av OBI.

http://www.netfonds.no/quotes/release.php?id=20181102.OBI.20181102S6


#757

And there is your late breaking abstract announcement :smiley:


#758

Nydelig!

@Larsmkn nå burde markedet våkne!


#759

Ja, blir spennende dette! Det var utrolig få slike abstract som var tilgjengelig for utdeling, og det som var kritetiene for utdeling gir jo litt vann i munn!


#760

Så langt i dag så har jo dette vært moro! Volum og omsetning er fortsatt begredelig, men man må jo begynne ett sted sted. 5% i går og 9% i dag er en veldig god start på det vi får håpe er begynnelsen på en opptrend. Så får vi håpe på raketten, toget som går, kursen som står i 100kr og alt det der :smile:


#761

#762

Veldig gode nyheter. Du etterlyste gravere, men jeg synes du klarer deg utmerket på egenhånd :+1:


#763

Ja, men jeg er lat så jeg vil at noen andre skal gjøre det for meg! :stuck_out_tongue_closed_eyes:


#764

http://www.netfonds.no/quotes/release.php?id=20181105.OBI.20181105S2


#765

05/11-2018 07:00:00: (BGBIO) BerGenBio ASA: Share options to primary insiders

Bergen, Norway, 5 November 2018 - The board of directors in BerGenBio ASA (the “Company”) (OSE:BGBIO) has granted options to primary insiders. The annual general meeting in the Company at 14 May 2018 approved the share options program. Options granted under the option program is vested over a three-year period and each option, when exercised, will give the right to acquire one share in the Company. A total of 277,000 share options were granted at an exercise price at NOK 28.50, of this the following was granted to primary insiders (total holdings of share options following this grant):
Richard Godfrey - CEO: 50,000 (1,117,484)
Rune Skeie - CFO: 20,000 (44,090)
James B. Lorens - CSO: 7,000 (717,707)
Anthony Brown - Director of research: 10,000 (186,499)
Endre Kjærland - Associate Director of IP and Contracts: 10,000 (95,225)
Julia Schoelermann - Associate Director of Business development: 20,000 (100,418)
Sonia Rodrigues – Director of Regulatory affairs: 10,000 (36,499)
Tone Bjaaland - Director of Clinical operations: 45,000 (45,000)

-End-

Contacts Richard Godfrey CEO, BerGenBio ASA [email protected] +47 917 86 304 Rune Skeie CFO, BerGenBio ASA [email protected] +47 917 86 513

This information is subject to the disclosure requirements pursuant to section 5-12 of the Norwegian Securities Trading Act.

Ekstern link: https://newsweb.oslobors.no/message/462766

Bugg i botten, @pdx?


#768

My bad! Leste feil. Trodde de hadde løst dem inn til 28kr. :see_no_evil::+1:

Kanskje for mye å be om at innsidere laster opp så mye til forsåvidt ok priser sett fra et aksjonærstandpunkt :sweat_smile:


#769

Kjekt å se opsjoner med noenlunde jordnær pris.


#770

Når det gjelder denne studien de har fått late breaking abstract i, bemcentinib + Keytruda i Advanced NSCLC. Er det altså ikke den studien de for litt siden gav resultater på?


#771

Jo, de presenterte resultater på den ved WCLC for litt siden, derfor litt overraskende at de fikk late-breaking på den. Det er kanskje en mer omfattende analyse av alle pasientene i første serien, pluss oppdatering på respons. Det var fortsatt noen som SD med respons ongoing sist de meldte resultater. Lov å håpe at noen av dem har blitt PR :sweat_smile: Immunterapi kan noen ganger ta litt tid før man får full utelling.


#772

Presentert 25. SEPTEMBER @ WCLC
Late breaking til en annen konferanse to måneder etterpå.

Det må jeg si er veldig spennende.


#773

Ja, den bugger. Er på saken :slight_smile: