BergenBIo med melding i dag;
Bergen, Norway, 3 April 2017 8am (CET): BerGenBio ASA, a clinical-stage biopharmaceutical
company developing novel, selective Axl kinase inhibitors for multiple cancer indications reported
study data on its first-in-class Axl inhibitor, BGB324 in preclinical models of lung and breast
cancer in a poster presentation at the American Association for Cancer Research (AACR) Annual
Meeting 2017 in Washington, DC. The study data confirmed Axl to be a key factor in tumor
resistance to the emerging class of cancer immunotherapies referred to as immune checkpoint
inhibitors (CPIs); these results provide further evidence supporting Axl inhibition as a mechanism
that can be targeted through combination therapy with BGB324. Furthermore, the data showed
that treatment with BGB324 led to enhanced activation of the anti-tumor immune response.
In a breast tumor model, treatment with the CPIs anti-CTLA4/PD1 increased Axl expression, which
correlated with a lack of response to these CPIs. Adding BGB324 to anti-CTLA4/PD1 led to
durable primary tumor clearance compared to treatment with CPIs. In the lung cancer model,
BGB324 in combination with anti-PD1/PDL1 CPIs significantly inhibited tumor growth compared to
treatment with anti-PD1/PDL1 alone.
Richard Godfrey, Chief Executive Officer of BerGenBio, commented:
“Inhibiting AXL with BGB324 potentiates the body’s innate response and counteracts tumor
resistance to immune checkpoint inhibitors. This preclinical data is very encouraging and suggests
an enormous potential for BGB324’s clinical utility in combination with immune checkpoint
inhibitors. We recently announced a clinical collaboration with MSD, where BerGenBio will sponsor
two Phase II trials with BGB324 in combination with KEYTRUDA, in adenocarcinoma of the lung
and triple negative breast cancer. The decision to sponsor these exciting combination clinical
trials was informed by the data presented today.”
The details of the poster presentations are as follows:
BGB324, a selective small molecule inhibitor of receptor tyrosine kinase Axl, abrogates tumor
intrinsic and microenvironmental immune suppression and enhances immune checkpoint inhibitor
efficacy in lung and mammary adenocarcinoma models
- Session: PO.IM02.01 T-cell Immunity to Cancer: New Progress
- Poster presentation 626 / poster board 30
- Sunday, 2 April 2017 1:00 PM - 5:00 PM (ET), Convention Center, Halls A-C, Poster Section
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A second poster describing a recently opened investigator-led Phase II randomized clinical study
with BGB324 in combination with dabrafenib/trametinib or pembrolizumab in melanoma patients
will be presented by the principle investigator Dr. Oddbjørn Straume, consultant oncologist at
Haukeland University Hospital and Professor at the University of Bergen Center for Cancer
Biomarkers. In parallel to this study, an extensive biomarker discovery and validation programme
will be executed.
A Phase Ib/II randomised open label study of BGB324 in combination with pembrolizumab or
dabrafenib/trametinib compared to pembrolizumab or dabrafenib/trametinib alone, in patients with
advanced non-resectable (Stage IIIc) or metastatic (Stage IV) melanoma
- Session: PO.CT02 Phase III Clinical Trials and Phase II/III Clinical Trials in Progress
- Poster presentation CT056 / poster board 6
- Monday, 3 April 2017 1:00 PM - 5:00 PM (ET), Convention Center, Halls A-C, Poster Section
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