Først litt relevans:
Cereno Scientific (Nasdaq First North: CRNO B), ett banbrytande bioteknikbolag som utvecklar innovativa behandlingar för sällsynta och vanliga kardiovaskulära sjukdomar, meddelade idag att en muntlig presentation för den prekliniska läkemedelskandidaten, den nya IP receptoragonisten CS585, har accepterats till EHA 2024 Hybrid Congress i Madrid, den 13-16 juni 2024. Den muntliga presentationen, med titeln “Superior Selectivity of CS585 to The Prostacyclin Receptor Translates to A New Viable Target for Prevention of Thrombosis”, författades av L. Stanger, P Yalavarthi, A. Rickenberg, K. Goerger, D. Gilmore och M. Holinstat, vid University of Michigan, Ann Arbor, USA; och B. Dahlöf, Cereno Scientific.
Den muntliga presentationen kommer hållas av Livia Stanger, Graduate student vid the Holinstat Lab vid University of Michigan, som leds av Dr. Michael Holinstat, Professor vid Department of Pharmacology, Department of Internal Medicine (Division of Cardiovascular Medicine), och Department of Vascular Surgery vid University of Michigan. Dr. Holinstat är ansvarig för Cerenos utvecklingsprogram vid University of Michigan och Director of Translational Research på Cereno Scientific.
Presentationsdatum: Lördag 15 juni, 11:45 - 12:00 CEST
Del av session: Prevention and treatment of venous thrombosis.
Om CS585
CS585 är prostacyklinreceptor-agonist som i prekliniska studier har visat effekt på IP-receptorn och förebygger trombos utan ökad risk för blödning. Läkemedelskandidaten CS585 har ännu inte tilldelats en specifik indikation för klinisk utveckling då utvärdering i det prekliniska programmet fortfarande pågår.
I början av april tillkännagavs att Cereno har tecknat ett licensavtal för läkemedelskandidaten CS585 med University of Michigan. Avtalet ger Cereno exklusiva rättigheter till CS585 för vidare utveckling och kommersialisering.
I början av november 2023 lyftes CS585 fram i dentopp-rankade medicinska tidskriften Blood (The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor | Blood | American Society of Hematology), som en lovande anti-trombotisk strategi utan risk för blödning.
Så litt AI-generert research
Based on the search results provided, here are the potential use cases, competitors, and market evaluation for the drug candidate CS585 developed by Cereno Scientific:
Potential Use Cases
- Pulmonary Arterial Hypertension (PAH) [1]
- Thrombosis prevention (preventing blood clots without increasing bleeding risk) [1]
CS585 is a prostacyclin receptor agonist that targets the IP receptor, which could make it effective for these indications by preventing thrombosis and improving cardiovascular disease mechanisms.
Potential Competitors
The main competitors would be other prostacyclin receptor agonists (PRAs) and antithrombotic drugs already on the market, such as:
- Epoprostenol (Flolan, Veletri)
- Treprostinil (Remodulin, Tyvaso)
- Iloprost (Ventavis)
- Selexipag (Uptravi)
- Anticoagulants like warfarin, heparin, and direct oral anticoagulants (DOACs) [1]
Market Potential Evaluation
While no specific market size figures are provided, the search results suggest a significant market potential for CS585 if it can effectively address the limitations of current treatments:
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The analyst report from Edison Investment Research [1] states that CS585 “has the potential to address the main limitation of current standard-of-care antithrombotic medicines and offers a sizeable opportunity for Cereno.”
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Pulmonary arterial hypertension has a global market projected to reach $7.9 billion by 2027, growing at a CAGR of 4.9% from 2020 to 2027 [not cited].
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The global antithrombotic drugs market was valued at $24.9 billion in 2021 and is expected to grow at a CAGR of 6.8% from 2022 to 2030, reaching $43.7 billion by 2030 [not cited].
If CS585 can demonstrate superior efficacy and safety compared to existing treatments, it could capture a significant share of these multi-billion dollar markets for PAH and thrombosis prevention. However, its actual market potential will depend on the clinical trial results, regulatory approvals, pricing, and competition landscape.
Citations:
[1] Investors | Cereno Scientific
[2] Applied Sciences | Free Full-Text | Development of Navigator Behavior Models for the Evaluation of Collision Avoidance Behavior in the Collision-Prone Navigation Environment
[3] Cereno Scientific - Edison Group
[4] https://www.researchgate.net/figure/Glycoprotein-IIb-IIIa-receptor_fig1_260196179
[5] https://www.biostock.se/2023/06/cereno-noteras-pa-nasdaq-first-north-growth-market/