Forøvrig så diskuteres kombinasjonen RIT+Rituximab som en erstatter for Rituximab+CHOP. Pasienter og leger er på jakt etter terapier som kan erstatte cellegift.
Nano står plassert med begge beina i en sweet spot!
''Several reports have documented similar efficacies and tolerable toxicities of radioimmunotherapy (RIT) consolidation and rituximab maintenance after initial R-chemotherapy of follicular lymphoma. The relative merits of these two interventions are currently under discussion. We now raise the question whether both RIT consolidation and rituximab maintenance should be used together aiming to augment the results achievable with R-chemotherapy.
In current practice, rituximab has appropriately assumed a dominant position in treatment of lymphoma both in combination with chemotherapy and as maintenance [9]. We now raise the question whether both rituximab and RIT should be used together as complementary methods to augment the results achievable with chemotherapy and whether this combined modality approach might afford additive or synergistic benefit. This strategy might also allow reducing chemotherapy as has been shown with abbreviated fludarabine combined with RIT [5]. An attenuated R-CHOP as recently described for elderly patients could possibly be envisaged in such a triple therapy approach’’
Litt om RIT innefor DLBCL:
Her får vi også en grei bekreftelse på hvorfor det er nyttig med et preparat som har et annet target enn Rituximab.
http://www.samo-workshop.ch/images/documents/arch_09/Lymphome09/Ketterer%20-%20Treatment%20of%20DLBCL.pdf
For ikke glemme denne her som Savepig sporet opp!