TIL NYE AKSJONÆRER I PCIB: Hvorfor fima-ditt og fima-datt?
Amphinex – fimaporfin: Nøkkelen eller den røde tråden i alle teknologiene til PCI Biotech
Se side 5 i presentasjonen:
http://pcibiotech.no/wp-content/uploads/2020/05/200526-ABGSC-Life-Science-Summit.pdf
Hvordan omtaler National Cancer Institute (NCI) fimaporfin–Amphinex og PCI i dag?
fimaporfin
A synthetic light-activated compound composed of three benzenesulfonic acid isomers: fimaporfin A (TPCS2a; tetraphenyl chlorin disulfonate), fimaporfin B, and fimaporfin C, with potential photosensitizing activity upon photodynamic therapy (PDT) . Upon intradermal administration, fimaporfin is incorporated into the tumor cells’ endosome and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate in the endosomal and lysosomal compartments; upon local activation by light, fimaporfin produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic agents are released into the tumor cell cytosol. This photochemical internalization (PCI) method can enhance the efficacy and selectivity of cytotoxic agents. Check for active clinical trials using this agent. (NCI Thesaurus)
tetraphenyl chlorin disulfonate
A meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl chlorin disulfonate incorporates into the cell’s endosome and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate in endosomal and lysosomal compartments; upon local activation by light, tetraphenyl chlorin disulfonate produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic agents are released into the tumor cell cytosol. This photochemical internalization (PCI) method can enhance the efficacy and selectivity of cytotoxic agents. Check for active clinical trials using this agent. (NCI Thesaurus)
Foreign brand name: |
Amphinex |
Code name: |
TPCS2a |
PS. Bare et kort notat foreløpig. Skal se om jeg finner mer stoff om struktur og syntese av tryllemiddelet Amphinex - fimaporfin… Hører naturlig hjemme i Fundamental-tråden til slutt.