Får ta med seg denne først tenker jeg (holdes i kveld):
Combination light-based therapies to treat pancreatic cancer
Paper 11070-124
Time: 12:30 PM - 12:45 PM
Author(s): Pilar Acedo, Ismahan Mahamed, Alex Ney, Andres Garcia, Univ. College London (United Kingdom); Pal Selbo, The Norwegian Radium Hospital (Norway); Patricia Sancho, Barts Cancer Institute (United Kingdom); Alexander J. MacRobert, Stephen P. Pereira, Univ. College London (United Kingdom)
Hide Abstract
Add To My Schedule
Pancreatic cancer is the 4th leading cause of cancer related death and is associated with poor survival rates. The biological complexity of pancreatic tumours leads to poor drug bioavailability and challenges efficient drug delivery. Photochemical internalisation (PCI) combines the use of low-dose photodynamic therapy (PDT) and chemotherapeutic agents. In our study, PCI showed a synergistic enhancement of the cell-killing effect of saporin and gemcitabine at significantly lower doses compared to monotherapies (p<0.001). This enhanced cytotoxic effect was demonstrated using established cell lines and patient-derived cells in both 2D and clinically relevant 3D models.