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AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines

Published: November 10, 2021

https://www.cell.com/molecular-therapy-family/oncolytics/fulltext/S2372-7705(21)00150-9 (DOI)

Recent reports have shown that Zika virus (ZIKV) has oncolytic potential against human glioblastoma (GBM); however, the mechanisms underlying its tropism and cell entry are not completely understood. The receptor tyrosine kinase AXL has been identified as an entry receptor for ZIKV in a cell-type-specific manner. Interestingly, AXL is frequently overexpressed in GBM patients. Using commercially available GBM cell lines, we first show that cells expressing AXL are permissive for ZIKV infection, while cells that do not express AXL are not.

Furthermore, inhibition of AXL kinase using R428 and antibody blockade of AXL receptor strongly attenuated virus entry in GBM cell lines. Additionally, CRISPR knockout of the AXL gene in GBM cell lines completely abolished ZIKV infection, significantly inhibited viral replication, and significantly reduced apoptosis compared with parental lines. Lastly, introduction of AXL receptor into non-expressing cell lines renders the cells susceptible to ZIKV infection.

Together, these findings demonstrate that ZIKV entry into GBM cells in vitro is mediated by the AXL receptor and that following cell entry, productive infection is cytotoxic. Thus, ZIKV is a potential oncolytic virus for GBM.

(Bemcentinib, also known as BGB324 or R428)

18 Likes

Blir spennende å få resultatene fra Glioblastom studien i USA, tipper mot slutten av 2022.

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BerGenBio announces exclusive in-license of key intellectual property rights from UT Southwestern Medical Center

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BerGenBio ASA: Notice of Extraordinary General Meeting

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Financial calendar

Hver måned kårer jeg det jeg kaller Teksperter™ for noen av de mest populære investeringene våre :slight_smile:

Det er de 3 medlemmene som har fått flest likes på innleggene sine de siste 90 dagene. Teksperter™ får også en unikt merke på profilen sin og et trofé-ikon ved siden av navnet sitt. Du kan bli Tekspert™ i flere aksjer/investeringer, og troféet vil bare vises i tråder der du er Tekspert™.

Her er denne månedens Teksperter™ og det mest likte innlegget deres fra de siste 90 dagene:

  1. @anon28800809 (741 likes)
  1. @Roc (303 likes)
  1. @Hayen (127 likes)

Resten av topp 10:

  1. @Scrivener (85 likes)

  2. @vcp (85 likes)

  3. @Direkte (73 likes)

  4. @Multiple (67 likes)

  5. @Realize_1 (66 likes)

  6. @PankPinter (58 likes)

  7. @Ekornet (53 likes)

Gratulerer!

BerGenBio - Mandatory notification of trade by Primary Insiders

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Må mangle en desimal der, skal markedet få troen på at CEO, har overbevisningen.

Walk the talk.

Men riktignok bedre enn Godfrey.

1 Like

Sign on fee det der.:slight_smile: så det er du og jeg som har kjøpt til han sånn i grove trekk​:joy::clap:

Ikke verd vatten då :grinning_face_with_smiling_eyes:

BerGenBio ASA: Extraordinary General Meeting held

BERGENBIO APPOINTS ANDERS TULLGREN AS CHAIRMAN OF BOARD

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Det var vel ny styreleder som skulle få sign-on bonus for aksjekjøp? 25000 aksjer. Så CEO’s kjøp er vel fra egen lomme??

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Ja, ganske sikker på at du har rett i det.

BERGENBIO - Mandatory notification of trade by Primary Insider

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Og snart kommer ny melding også om allerede annonserte 25k innsidehandel av Anders Tullgren!

3 Likes

BerGenBio - Mandatory notification of trade by Primary Insiders

22 Likes

BerGenBio - Mandatory notification of trade by Primary Insider

18 Likes

Mange som lider av dette, et marked en ikke skal kimse av.

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Correcto.
Non alcoholic fatte liver disease brer om seg. Hovedsaklig pga fedme-epidemien. USA er jo eksponenten for det, men brer jo om seg i hele den vestlige verden. Respekterer dernest ingen landegrenser.

3 Likes