Her er interessant lesestoff fra mars/april 2020, dersom du vil utfordre din initielle tvil:
“We hypothesize that general BCG vaccination policies adopted by different countries might have impacted the transmission patterns and/or COVID-19 associated morbidity and mortality.”
" Ordinarily, a vaccine provides protection from a particular pathogen, by inducing effector mechanisms directed to that pathogen. However, certain live attenuated vaccines like the Bacillus Calmette–Guerin (BCG), an attenuated strain of Mycobacterium bovis, provide protection not only to a specific pathogen, but also against unrelated pathogens, some of which cause acute respiratory tract infections.
The underlying mechanism for the BCG vaccination-induced non-specific protection is thought to be mediated via the induction of innate immune memory, or “trained immunity, as was first proposed by Netea and collaborators. Trained-immunity inducing agents reprogramme bone marrow hematopietic stem cells and multipotent progenitors through epigenetic and metabolic changes, resulting in a more robust response in differentiated innate immune cells, following encounter with a pathogen.
Of interest, in a randomized placebo-controlled human study, BCG vaccination was demonstrated to induce epigenetic reprograming in monocytes, conferring protection against experimental infection with an attenuated yellow fever virus vaccine strain."
“Case numbers per million people in countries with a national BCG vaccination programme were statistically significantly lower than those that did not have or have ceased their national BCG vaccination programs (P<0.0001)”
“Since BCG vaccination was previously demonstrated to prevent acute respiratory tract infections even in the elderly, until a specific vaccine is developed, SARS-CoV-2 vulnerable populations could be immunized with BCG vaccines. Such a strategy would also be suitable for frontline health personnel.”