Så hvorfor er dette relevant? Fordi Nano har spennende funn med Humalutin + Olaparib( BRCA-hemmer)
Og hvem skal kombinere RIT/TAT med AZ sin PARP-hemmer? Jepp, Fusion pharma som AZ inngikk en deal med før jul.
Tror dere AZ ser samme muligheten sammen med Betalutin/Humalutin/Alpha37 også?
The combination of Humalutin and Olaparib, a small molecule inhibitor that inhibits the PARP enzyme whose function is to repair DNA single strand break (SSB) was explored. Inhibited repair of SSB in combination with radiation-induced DNA damage results in fatal irreparable DNA double strand breaks. The combination resulted in synergistic effects in NHL cells.
The results indicate the potential clinical benefit of combining Betalutin with CD20 targeting immunotherapy as well as combining Humalutin with PARP inhibitors.
(Fra Fusion sin presentasjon)