FimaNAc
Kan ikke forstå noe annet enn at fimaNAc må være verdt store summer.
Fra selskapets hjemmeside:
Nucleic acids
The fima NAc technology provides a targeted intracellular delivery technology for nucleic acid therapeutics. Several forms of nucleic acids are widely acknowledged to have a large potential as therapeutic agents, and numerous clinical trials are underway. The therapeutic potential of such compounds is challenged by the obstacles to achieve adequate intracellular access, which the fima NAc technology may resolve.
Most types of nucleic acids have their molecular targets inside the target cells, but nucleic acids are, by factors of their size and charge, notoriously difficult to deliver in large enough payloads inside a cell to give an effective therapeutic response. Nucleic acids are in most cells taken up by endocytosis, but are then trapped in endosomes, constituting a barrier severely limiting the therapeutic effect that can be achieved. Thus, nucleic acids are very good candidates for enhancement by an endosomal release technology like fima NAc , and preclinical experiments have shown that fima NAc can give a substantial improvement in the effect of very important classes of nucleic acids (e.g. mRNA, siRNA and DNA).
