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PCIB: mRNA er i vinden

Fant ett par linker, men sier ikke med det att FimaNAc er løsningen her, men det er ett problem og NAc kan være en løsning.

Allzheimer’s og siRNA:

However, there are several issues regarding the delivery of siRNAs, including the blood-brain barrier, short circulation lifetime, enzymatic degradation, insufficient tissue penetration, cell endocytosis and impaired cytosolic transport.

ALS og CRISPR:

More and more, companies are focusing on developing better delivery technologies, which promise to expand treatment “payload” and target cells more precisely to improve safety and effectiveness.

Det jobbes med Parkinson’s (og mye annet selvfølgelig), men der er de ikke kommet så langt dessverre, men snakk om LncRNA og mRNA og sikkert mye annet også.

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Front. Bioeng. Biotechnol., 18 March 2021 |

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https://www.ous-research.no/home/berg/group%20members/14517

https://news.ycombinator.com/item?id=27681418

Utdrag fra nederste link:

espenwa
5 months ago next [–]

When it comes to the problem of targeting, one interesting and promising tech is photochemical internalisation [https://en.m.wikipedia.org/wiki/Photochemical_internalizatio…], where you put the mRNA inside photosensitive molecules (and not lipids) and then shine some light on the tissue/organ where you want the mRNA delivered. Where activated by the light, the molecules then enter the cells, dissolves and deliver the mRNA. The Norwegian company PCI Biotech has a tech they call fimaNAc for doing this with naked mRNA.

https://www.pcibiotech.no/nucleicacids

This presentation has a lot of illustrations and explanations:

https://www.pcibiotech.no/s/PCI-Biotech-SMi-RNA-Therapeutics…
\ 40x1 monocasa 5 months ago parent next [–]

What happens to the unactivated mRNA in that case? I was under the impression that it was typically the actual use of the mRNA by the ribosomes that broke them down generally, but I could be off base there.


\ 80x1 gus_massa 5 months ago root parent next [–]

The same mRNA can be used by multiple ribosomes. More info and “photos”: https://biology.stackexchange.com/questions/54752/can-mrna-b…


\ 120x1 monocasa 5 months ago root parent next [–]

Sure, it isn’t destroyed immediately and the mRNA is used multiple time, but that’s still ultimately the ribosomes damaging the mRNA from use. My question is around how they break down if there aren’t ribosomes involved (ie. if the capsules above aren’t opened because they weren’t exposed to the light trigger).


\ 160x1 sudosysgen 5 months ago root parent next [–]

Eventually the capsule will break down, be filtered out or be destroyed by the immune system and any RNA left will be broken down by RNAse.


\ 200x1 gus_massa 5 months ago root parent next [–]

More info about RNA destruction and RNAse Ribonuclease - Wikipedia


\ 40x1 kmarc 5 months ago parent prev next [–]

This is one of the most amazing things I’ve read lately (apart from mRNA based vaccination itself). Thanks for sharing.


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Hvor fort de klarer å lage ny variant av mRNA vaksine viser nok en gang hvor bra mRNA vaksiner er.

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Dette innlegget ble rapportert og er midlertidig skjult.

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Fundamentalt er det kanskje enda mer spennende.
Fin oversikt i link over deals!

Utdrag:

Interestingly, analysis of recent deals shows that interest in mRNA is not limited to development of mRNA-based vaccines or therapeutic platforms; there has also been significant activity in related technologies and manufacturing capabilities.

In recent years however, larger pharma companies have been entering the field either through partnering or acquisitions.

Given the importance of the delivery system for mRNA vaccines and therapies, a number of mRNA focussed companies have entered into partnerships with companies specialising in delivery technology,

We have set out below a selection of collaboration and licence deals relating to mRNA from this year (2021). Given the excitement surrounding the field of mRNA research and its broad potential applications, we expect to continue to see a healthy pipeline of collaborations and licence partnerships in coming years.

The recent success of mRNA vaccines, which has demonstrated both the safety and efficacy of the technology in the fight against COVID-19, has triggered a wave of interest in mRNA. This trend is illustrated by the significant number of mRNA related partnerships, acquisitions and fundraisings we have seen over the past year, including in manufacturing and related technologies. Research and development on mRNA, which had previously been concentrated in a cluster of smaller biotech companies, is increasingly becoming a key element of the pipeline of a number of large pharma companies and mRNA focussed biotech companies. As such, companies such as Moderna and BioNTech have seen their valuations soar.

Whenever there is significant activity in any sector of the market, there are always rumours of a market bubble. With that in mind, it is important to remember that, despite the swirling excitement, mRNA is still a nascent field. The fight against COVID-19 has been an important proving ground for the technology, but if mRNA is to live up to its much vaunted potential, we will need to see positive results coming out of clinical trials for other indications. While the early pace of development in the mRNA field was slow (see our article on the history of mRNA research here), given the current level of investment and momentum in the field, we expect we will find out sooner rather than later if mRNA really is ushering in a new era of genetic medicine.

https://www.bloomberg.com/news/articles/2021-09-13/chinese-firm-buys-canada-mrna-vaccine-tech-in-500-million-deal

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Utrolig synd BioNTech avsluttet samarbeidet med PCIB. Skulle tro PCIB sin teknologi burde passe inn i BioNTech sin mRNA strategi spesielt mot kreft.

Aktivere immunforsvar, T celle respons, målrettet levering osv. osv.

Synd.

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