Her er en fersk podkast (21. februar) fra tre av porteføljeforvalterne i Janus Henderson som har et ansvar for å investere i small- og mid size biotech.
Ikke noe om Ulti eller shorting, men greit å lese litt hva de tenker om sektoren de jobber mot (det går an å trykke “view transcript” på siden):
“But now, we have all-new technologies that we’re developing for cancer, all-new modalities of treating this. So, we have everything from cell-based therapies to engineered antibodies.”
“So, for example, instead of just giving chemotherapy – which we’ve been doing for about 70 years, which can kill cancer cells but unfortunately kills a lot of our healthy cells, as well – now we have precision-guided missiles, antibody drug conjugates. We can attach a chemotherapy molecule to a targeted antibody, deliver it directly to cancer cells, and that results in both better efficacy but also better safety and tolerability. “
“the framework that we use is called the 90/90 rule. And this refers to the clinical and commercial risks of developing a new therapy.”
“ So, the first part represents the fact that 90% of the drugs that begin human clinical testing will never make it all the way to market.”
“ And then the second element of the 90/90 rule is that commercial risk. And there, what we found is consensus estimates from Wall Street are wrong 90% of the time in terms of predicting new product launches.”
“ …the consensus view has shifted dramatically in the last year to an expectation of a soft landing, and yet we’ve had an inverted yield curve and declining money supply. And these are factors that historically have led to recession with a high probability. So, if we end up with a significantly slowing economy or recession, I think the healthcare sector is a really good place to be.”
“we are seeing a lot of very attractive valuations that we believe could lead to an increase in M&A activity. And in fact, in Q4 of 2023, there were nine deals announced of over $1 billion in the healthcare sector, which is more like what you see in a typical year, not in a quarter. And there’s already been a couple of deals year to date. So, we’re seeing that trend continue.”
Det virker som de er ganske positive til bioteksektoren generelt, men de har jo (naturligvis) hovedfokus på USA.