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"Betalutin® was evaluated in combination with rituximab, a CD20-targeting immunotherapy that activates immune cells to attack and decimate the tumour cells. The combination resulted in synergistic therapeutic effects in both rituximab-responding and rituximab-resistant NHL animal models.
The combination of Humalutin and Olaparib, a small molecule inhibitor that inhibits the PARP enzyme whose function is to repair DNA single strand break (SSB) was explored. Inhibited repair of SSB in combination with radiation-induced DNA damage results in fatal irreparable DNA double strand breaks. The combination resulted in synergistic effects in NHL cells.
The results indicate the potential clinical benefit of combining Betalutin with CD20 targeting immunotherapy as well as combining Humalutin with PARP inhibitors."
Sistenevnte bygger fint opp om rasjonalet for å kjøre Humalutin i første og/eller andre linje i kombinasjon med en PARP-inhibotor.